Dynamics of the humoral immune response to a prime-boost Ebola vaccine: quantification and sources of variation
Published in Journal of virology, 2019
In this paper data from three phase 1 trials of a 2-doses vaccine against Ebola virus performed by the EBOVAC1 Consortium are analyzed. A mathematical model based on ODEs is used to characterize the dynamics of the humoral response after the second dose immunization up to 1 year of followup: it allows to estimate the durability of the antibody response and the influence of different factors on the dynamics of the humoral response.
Recommended citation: Pasin, C., Balelli, I., Van Effelterre, T., et al. (2019). Dynamics of the humoral immune response to a prime-boost Ebola vaccine: quantification and sources of variation. Journal of virology, 93(18), e00579-19.