Parameter estimation in nonlinear mixed effect models based on ordinary differential equations: an optimal control approach

We present a parameter estimation method for nonlinear mixed effect models based on ordinary differential equations (NLME-ODEs). The proposed method aims at regularizing the estimation problem in presence of model misspecifications, practical identifiability issues and unknown initial conditions, using a control theory approach.

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Recommended citation: Clairon, Q., Pasin, C., Balelli, I., et al. (2021). Parameter estimation in nonlinear mixed effect models based on ordinary differential equations: an optimal control approach. arXiv preprint arXiv:2102.11543.